Surrey Heartlands

Joint Formulary & PAD

Modafinil - Narcolepsy

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Status 1

Amber
Formulations :
  • Tablets
Formulary Status :
Primary Care
ASPH
RSFT
SASH
SABP
Associated Icons :
BNF SPC
Restrictions / Comments :

Documentation

Shared Care
Modafinil for Narcolepsy - Amber Shared Care ESHUT - PCN November 2014
Shared Care
Modafinil for Narcolepsy - Amber Shared Care - PCN November 2014
Evidence Review
Modafinil - Evidence Review - Jul 2014
Webpage
Modafinil (Provigil): increased risk of congenital malformations if used during pregnancy - MHRA

PAD Profile

ChemicalSubstance :
Modafinil
Indication :
Narcolepsy
Group Name :
Keywords :
sleepiness, fatigue
Brand Names Include :
Provigil
Important Information :
Pregnancy safety warnings.
Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
4

Other Indications

Below are listed other indications that Modafinil is used to treat.

Other Drugs

Below are listed other drugs that are used to treat Narcolepsy.

Committee Recommendations (3)

09 Aug 23 - Surrey Heartlands Medicines Safety Committee (MSC)

The MHRA published in the Drug Safety Update (Dec 2014, updated November 2020) an update on the safety of modafinil, in regard to its effect on unborn children. Modafinil potentially increases the risk of congenital malformations when used in pregnancy.

Modafinil should not be used during pregnancy and women of childbearing potential must use effective contraception during treatment and for 2 months after stopping modafinil.

See link to the MHRA information for further information   https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/936767/Nov-2020-DSU-PDF-1.pdf

03 May 17 - Surrey & North West Sussex Area Prescribing Committee (formerly Prescribing Clinical Network)
GENERIC Modafinil has been considered by the PCN and has been assigned a AMBER traffic light status

NOTE - the branded product, Provigil, was considered BLACK at the PCN in May 2017.
03 Sep 14 - Surrey & North West Sussex Area Prescribing Committee (formerly Prescribing Clinical Network)
Modafinil is only licensed for narcolepsy (with or without cataplexy). Agreed as Amber (suitable for shared care). Shared Care Agreement under development. Modafinil for any other unlicensed indication was granted a RED traffic light status.