Mercaptopurine - Hepatology Indications

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Status 1

Amber

Formulations :

Oral suspension
Tablets

Formulary Status :

Primary Care

ASPH

RSFT

SASH

SABP

Associated Icons :

Off Label

SPC

Restrictions / Comments :

Documentation

Shared Care

Azathioprine and 6MP for non-transplant indications -National shared care - update February 2026.docx

PAD Profile

ChemicalSubstance :

Mercaptopurine

Indication :

Hepatology Indications

Group Name :

Keywords :

RMOC, national shared care, autoimmune hepatitis, auto-immune hepatitis, 6-MP

Brand Names Include :

Puri-Nethol, Xaluprine

Important Information :

Tablets and oral suspension are NOT bioequivalent. Do not confuse with mercaptamine (similar name) - https://www.gov.uk/drug-safety-update/mercaptamine-and-mercaptopurine-confusion-between-drug-names

Click on drug name for specific shared care document.

General principles for shared care found here: https://surrey.res.services/PAD/Profile/NonClinicalProfile/9136

https://www.gov.uk/drug-safety-update/thiopurines-and-intrahepatic-cholestasis-of-pregnancy

Latest Additions Date From :

Latest Additions Date To :

Guidelines :

Supporting Documents :

Committee Recommendations (1)

05 Oct 22 - Surrey Heartlands Integrated Care System Area Prescribing Committee (APC)

The Surrey Heartlands Integrated Care System Area Prescribing Committee (APC) has agreed the National Shared Care Protocol for azathioprine and mercaptopurine for patients in adult services (non- transplant indications)

Other Indications

Below are listed other indications that Mercaptopurine is used to treat.

Other Drugs

Below are listed other drugs that are used to treat Hepatology Indications.