Surrey Heartlands

Joint Formulary & PAD

Midazolam maleate (Epistatus) - Status epilepticus

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Status 1

Blue
Formulations :
  • Pre-filled oral syringe
Formulary Status :
Primary Care
ASPH
RSFT
SASH
SABP
Associated Icons :
BNF SPC
CD
NICE
Restrictions / Comments :
Important
Prescribe by BRAND (Epistatus). However, Buccolam is currently the preferred, lower-cost in patients over 3 months of age
 

Status 2

Red
Formulations :

No records returned.

Formulary Status :
Primary Care
ASPH
RSFT
SASH
SABP
Associated Icons :
BNF SPC
CD
Un
Restrictions / Comments :
Important
Unlicensed preparations / specials have a Red traffic light status - not for prescribing in primary care.
 

Status 3

Red
Formulations :
  • Liquid
Formulary Status :
Primary Care
ASPH
RSFT
SASH
SABP
Associated Icons :
BNF SPC
CD
R
Restrictions / Comments :
Important
ASPH Paediatrics only - (high-cost) unlicensed midazolam liquid 12.5mg/5ml sugar free.

Documentation

Information
Epilepsy in pregnancy - Royal College ObGyn Guidelines Jun16.pdf

PAD Profile

ChemicalSubstance :
Midazolam maleate (Epistatus)
Indication :
Status epilepticus
Group Name :
Keywords :
midazolam oral solution, midazolam oromucosal solution, midazolam buccal, buccal midazolam
Brand Names Include :
Epistatus
Important Information :
Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
1
Traffic Light Entries :
3

Other Indications

Below are listed other indications that Midazolam maleate (Epistatus) is used to treat.

  • No records returned.

Other Drugs

Below are listed other drugs that are used to treat Status epilepticus.

Committee Recommendations (1)

03 Apr 24 - Surrey Heartlands Integrated Care System Area Prescribing Committee (APC)

Status Epilepticus in all age groups (over 3 months of age)

The Surrey Heartlands Area Prescribing Committee agreed that:

  • Buccolam (midazolam hydrochloride) and Epistatus (midazolam maleate) will be assigned a Blue traffic light status (no information sheet required) for all ages over 3 months of age when used for Status Epilepticus.
  • Buccolam and Epistatus should be prescribed by brand (in line with MHRA & NICE guidance) https://surreyccg.res-systems.net/PAD/Guidelines/Detail/5045
  • The least costly preparation should be used at the point of initiation (currently Buccolam - April 2024)

NOTE: the use of Buccolam and Epistatus in patients aged 18 years and over is off-label.

Unlicensed specials will be assigned a RED traffic light status.

Patients using unlicensed preparations should be reviewed for a potential switch to the licensed product following liaison with their specialist.