Joint Formulary & PAD

Denosumab - Osteoporosis

I agree that in using this database I understand that this platform only provides guidance on local prescribing policy and that all prescribing decisions are ultimately the responsibility of the clinician.

Status 1

Green (see narrative)
Formulations :
  • Subcutaneous injection (sc)
Associated Icons :
Restrictions / Comments :
Important
Patients with a CKD of 4 or 5 and patients with a T-score of < -4.5 to remain under specialist care.

PAD Profile

ChemicalSubstance :
Denosumab
Indication :
Osteoporosis
Group Name :
Keywords :
PSDs, patient specific directions, postmenopausal osteoporosis
Brand Names Include :
Prolia
Important Information :

Rheumatology only in secondary care. 
Restricted to use in patients for whom bisphosphonates are unsuitable.

Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
4

Committee Recommendations (4)

Denosumab for Osteoporosis  – Information for GPs: Ashford and St. Peter's Hospitals NHS Foundation Trust (ASPH) and North West Surrey Place only.  Guidance has been produced to clarify for GPs the process used within ASPH to inform a patient’s GP that they have been initiated on subcutaneous denosumab injection

Users are signposted to use the NICE CKS guidance for the management of osteoporosis, available at https://cks.nice.org.uk/topics/osteoporosis-prevention-of-fragility-fractures/management/management/

The National Osteoporosis Guideline Group UK (NOGG) clinical guidelines are available here-  https://www.nogg.org.uk/sites/nogg/download/NOGG-Guideline-2021-g.pdf

The Surrey Heartlands Integrated Care System Area Prescribing Committee agreed the reviewed Denosumab Prescribing Information to support initiation and ongoing administration in primary care.

Patient Specific Directions (PSDs) are often used to enable non-medical practitioners (practice nurses, health care assistants) to administer specific medicines for specific conditions. A PSD tempate for EMIS system users has been developed by a local GP practice to improve the consistency and content of their Denosumab PSDs. This PSD template (among others) is available from your local Medicines Management Team should your practice wish to adopt / adapt it. Please contact your local Medicines Management Team for assistance

Other Indications

Below are listed other indications that Denosumab is used to treat.