Joint Formulary & PAD

Melatonin - Insomnia in adults

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Status 1

Green
Formulations :
  • Modified release tablets
Associated Icons :
Restrictions / Comments :
Important
Preferred

Melatonin 2mg MR tablets are the recommended preferred 1st line product

Prescribe generically.  Circadin is NON-FORMULARY

 

Status 2

Green
Formulations :
  • Immediate release tablets
Associated Icons :
BNF SPC
Un
Restrictions / Comments :
Important

If immediate onset of action is required or crushed to aid swallowing

 

 

Status 3

Green
Formulations :
  • Oral solution
Associated Icons :
BNF SPC
Un
Restrictions / Comments :
Important

Reserved ONLY if feeding tube in situ, or significant swallowing difficulties, and the use of the whole or crushed tablets are unsuitable

 

 

Status 4

Non Formulary
Formulations :
  • Not Specified
Associated Icons :
BNF SPC
NFD1
NICE
Un
Restrictions / Comments :
Important

All formulations of melatonin for adults under 55 without neurodevelopmental disorders were agreed by APC as NON-FORMULARY

 

Status 5

Non Formulary
Formulations :
  • Capsules
Associated Icons :
BNF SPC
NFD1
Restrictions / Comments :
Important

Not a cost effective option

PAD Profile

ChemicalSubstance :
Melatonin
Indication :
Insomnia in adults
Group Name :
Keywords :
Brand Names Include :
Circadin
Important Information :

DO NOT PRESCRIBE FOR UNDER 55 years (without neurodevelopmental disorders)

Latest Additions Date From :
07 May 2025
Latest Additions Date To :
Guidelines :
Supporting Documents :
2
Traffic Light Entries :
5

Other Indications

Below are listed other indications that Melatonin is used to treat.

Other Drugs

Below are listed other drugs that are used to treat Insomnia in adults.

Committee Recommendations (1)

The Surrey Heartlands Integrated Care System Area Prescribing Committee has agreed that melatonin may be considered for for the short term (up to 13 weeks) adjunctive treatment of primary insomnia in patients aged 55 years or over, where sleep hygiene measures have failed, and insomnia is not likely to resolve soon. CBTi should be offered before melatonin (if available).

In all patients, sleep hygiene and behavioural interventions should be tried prior to considering medication for sleep disorders and should continue to be used alongside melatonin. Sleep | Healthy Surrey

Where treatment is continued beyond 2 years, patient to be advised of limited safety evidence beyond this timeframe and a discussion should be documented in clinical notes.

Melatonin is considered as GREEN status for this patient cohort.