Melatonin - Parkinson's disease
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Status 1
- Modified release tablets
On specialist recommendation
Melatonin 2mg MR tablets are the recommended preferred 1st line product
Prescribe generically. Circadin is NON-FORMULARY
Status 2
- Immediate release tablets
If immediate onset of action is required or crushed to aid swallowing
On specialist recommendation
Status 3
- Oral solution
Reserved ONLY if feeding tube in situ, or significant swallowing difficulties, and the use of the whole or crushed tablets are unsuitable
On specialist recommendation
Documentation
PAD Profile
Rapid eye movement sleep behaviour disorder. (RBD)
Other Indications
Below are listed other indications that Melatonin is used to treat.
Other Drugs
Below are listed other drugs that are used to treat Parkinson's disease.
- Amantadine hydrochloride
- Apomorphine hydrochloride
- Bromocriptine
- Cabergoline
- Clonazepam
- Co-beneldopa
- Co-careldopa
- Entacapone
- Foslevodopa with foscarbidopa
- Levodopa with carbidopa and entacapone
- Opicapone
- Orphenadrine hydrochloride
- Pergolide mesilate
- Pramipexole
- Procyclidine hydrochloride
- Rasagiline mesilate
- Ropinirole hydrochloride
- Rotigotine
- Safinamide
- Selegiline hydrochloride
- Tolcapone
- Trihexyphenidyl hydrochloride
Committee Recommendations (1)
The Surrey Heartlands Integrated Care System Area Prescribing Committee has agreed that melatonin may be considered to treat rapid eye movement sleep behaviour disorder (RBD) in people with Parkinson's Disease and sleep disturbance (unlicensed use), on request from a Parkinson's specialist.
In all patients, sleep hygiene and behavioural interventions should be tried prior to considering medication for sleep disorders and should continue to be used alongside melatonin. Sleep | Healthy Surrey
Where treatment is continued beyond 2 years, patient to be advised of limited safety evidence beyond this timeframe and a discussion should be documented in clinical notes.
A BLUE (on specialist recommendation) has been agreed.