Joint Formulary & PAD

Dosulepin hydrochloride - Depression

I agree that in using this database I understand that this platform only provides guidance on local prescribing policy and that all prescribing decisions are ultimately the responsibility of the clinician.

Status 1

Non Formulary
Formulations :
  • Not Specified
Associated Icons :
Restrictions / Comments :
Important

Not for initiation in new patients.

Existing patients may remain on therapy providing cardiac risk and toxicity has been considered. It is advised that patients who present with deterioration of mental health may require a review by the specialist.

PAD Profile

ChemicalSubstance :
Dosulepin hydrochloride
Indication :
Depression
Group Name :
Keywords :
Dothiepin, tricyclic antidepressants, tricyclics, TCAs, low value medicines, drugs of low clinical value, LVM, drugs of limited clinical value
Brand Names Include :
Prothiaden, Thaden
Important Information :
Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
6

Committee Recommendations (2)

At the Surrey and North-West Sussex Area Prescribing Committee (APC) held in June 2020, it was decided that all BLACK status drugs would have their review dates extended for 5 years without the need for a review.

If a clinician or provider wishes to change the traffic light status of any BLACK drug then they will need to submit a paper for change as per usual APC process.

The Prescribing Clinical Network does not recommend the use of dosulepin
Dosulepin will be considered BLACK on the traffic light system, prescribers should:
- NOT initiate dosulepin for any new patient;
AND
- Switch patients taking dosulepin to an alternative antidepressant

In exceptional circumstances where there is a clinical need for dosulepin to be prescribed in primary care this should be undertaken in a cooperation arrangement with a multidisciplinary team and / or other healthcare professional

Note - The Mood Hive and associated local depression and anxiety treatment guidelines have been removed from PAD.

Updated guidelines and resources for treating and managing depression in adults are being developed by Surrey & Borders Partnership. For current advice, in line with NICE guidance, please see the Clinical Knowledge Summaries - link provided below