Joint Formulary & PAD

Sodium valproate (NON childbearing potential) - Mania

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Status 1

Blue
Formulations :
  • Crushable tablets
  • Enteric coated tablets
  • Granules (slow release)
  • Modified release capsules
  • Modified release tablets
  • Oral solution
Associated Icons :
Off Label
SPC
Restrictions / Comments :

PAD Profile

ChemicalSubstance :
Sodium valproate (NON childbearing potential)
Indication :
Mania
Group Name :
Keywords :
valproate semisodium, mania, manic episodes, bipolar disorder, psychotic disorders, mood disorders
Brand Names Include :
Epilim, Epilim Chrono, Dyzantil, Epival CR, Episenta, Epilim Chronosphere
Important Information :

Off-label use. Licesned product is valproic acid (valproate semisodium).

Initiation and stabilisation by the mental health specialist team for at least 1 month before any request for transfer of prescribing responsbility to primary care.

See separate formulary entry for sodium valproate in people WITH childbearing potential - important pregnancy-prevention requirement.

Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
2

Committee Recommendations (2)

Three infographics have been produced to clarify in which situations review by two specialists may be required for patients who are prescribed valproate:
•    for female patients under 55 years old
•    for male patients under 55 years old
•    for male and female patients 55 years and older

The Surrey Heartlands APC reviewed the Blue traffic light status for sodium valproate when used in patients with mental health disorders (mania, bipolar disorder, psychotics disorders, compulsive and agressive behaviours) and WITHOUT child-bearing potential.

The Blue status remains with the expectation that treatment will be initiated and stabilised by a specialist and patients will receive a minimum of 1 month supply from the specialist before transfer of care.

No supplementary information sheet is required

Other Indications

Below are listed other indications that Sodium valproate (NON childbearing potential) is used to treat.