Vancomycin hydrochloride - Clostridioides difficile

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Status 1

Green

Formulations :

Capsules

Formulary Status :

Primary Care

ASPH

RSFT

SASH

SABP

Associated Icons :

BNF SPC

Restrictions / Comments :

Important

Restricted Use - for use when indicated by local trust antimicrobial guidelines, NICE condensed summary table of antimicrobial guidance or specialist microbiology recommendation. The APC notes that although current NICE guidelines recommend vancomycin first line for treatment of C diff, it is recognised that this was based on cost and in exceptional cases when a liquid is required, fidaxomicin granules are appropriate to prescribe as a licensed preparation that supports timely treatment.

Documentation

Guidelines (Local)

Supply of oral vancomycin and fidaxomicin for treating Clostridioides difficile in Primary Care - Mar 23

Evidence Review

Clostridioides difficile - APC briefing - November 2021.pdf

Webpage

Clostridioides difficile infection: antimicrobial prescribing - NICE guidance (NG199) - July 2021

PAD Profile

ChemicalSubstance :

Vancomycin hydrochloride

Indication :

Clostridioides difficile

Group Name :

Keywords :

c.diff infection, C.difficile infection, clostridium difficile infection, antibiotic, antibacterial, glycopeptide

Brand Names Include :

Vancocin, Matrigel

Important Information :

Latest Additions Date From :

Latest Additions Date To :

Guidelines :

Supporting Documents :

Other Indications

Below are listed other indications that Vancomycin hydrochloride is used to treat.

Other Drugs

Below are listed other drugs that are used to treat Clostridioides difficile.

Committee Recommendations (1)

03 Aug 22 - Surrey Heartlands Integrated Care System Area Prescribing Committee (APC)

ADVICE UPDATE:
The Surrey Heartlands Integrated Care System Area Prescribing Committee (APC) agreed the following in relation to prescribing of C.difficile treatments after a positive test for C.difficile.
Vancomycin oral treatment

GREEN traffic light status for treatment of C.diff. in adults as per NICE clinical guideline.
BLUE (on recommendation) traffic light status for children.

For any patient requiring a liquid preparation, fidaxomicin granules should be prescribed. The APC notes that although current NICE guidelines recommend vancomycin first line, it is recognised that this was based on cost and in exceptional cases when a liquid is required, fidaxomicin granules are appropriate to prescribe as a licensed preparation that supports timely treatment.

Follow link to Fidaxomicin information https://surreyccg.res-systems.net/PAD/Search/DrugConditionProfile/6508

SUPPLY

Vancomycin and fidaxomicin are not routinely stocked in community pharmacies but are usually obtainable on next-day delivery. However, at weekends and bank holidays, a local arrangement has been put in place whereby a small number of pharmacies will hold supplies. Please refer to the document below called "Supply of oral vancomycin and fidaxomicin for treating Clostridioides difficile in Primary Care - Mar 23"