Surrey Heartlands

Joint Formulary & PAD

Fidaxomicin - Clostridioides difficile

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Status 1

Green
Formulations :
  • Oral suspension
  • Tablets
Formulary Status :
Primary Care
ASPH
RSFT
SASH
SABP
Associated Icons :
BNF SPC
R
Restrictions / Comments :
Important
Granules (for oral suspension) should be used in patients requiring a liquid preparation. Restricted Use - for use when indicated by local trust antimicrobial guidelines, NICE condensed summary table of antimicrobial guidance or specialist microbiology recommendation. For any patient requiring a liquid preparation, fidaxomicin granules should be prescribed. The APC notes that although current NICE guidelines recommend vancomycin first line, it is recognised that this was based on cost and in exceptional cases when a liquid is required, fidaxomicin granules are appropriate to prescribe as a licensed preparation that supports timely treatment.

Documentation

Guidelines (Local)
Supply of oral vancomycin and fidaxomicin for treating Clostridioides difficile in Primary Care - Mar 23
Evidence Review
Clostridioides difficile - APC briefing - November 2021.pdf
Webpage
Clostridioides difficile infection: antimicrobial prescribing - NICE guidance (NG199) - July 2021

PAD Profile

ChemicalSubstance :
Fidaxomicin
Indication :
Clostridioides difficile
Group Name :
Keywords :
c.diff infection, C.difficile infection, clostridium difficile
Brand Names Include :
Dificlir
Important Information :
Latest Additions Date From :
Latest Additions Date To :
Guidelines :
Supporting Documents :
3

Other Indications

Below are listed other indications that Fidaxomicin is used to treat.

  • No records returned.

Other Drugs

Below are listed other drugs that are used to treat Clostridioides difficile.

Committee Recommendations (1)

01 May 24 - Surrey Heartlands Integrated Care System Area Prescribing Committee (APC)

The Surrey Heartlands Integrated Care System Area Prescribing Committee (APC) agreed a change in fidaxomicin traffic light status from Blue to GREEN.

This is to facilitate the prescribing of fidaxomicin following the recurrence of C diff infection within 12 weeks of a previous infection (as per NICE NG199).

For any patient requiring a liquid preparation, fidaxomicin granules should be prescribed.  The APC notes that although current NICE guidelines recommend vancomycin first line, it is recognised that this was based on cost and in exceptional cases when a liquid is required, fidaxomicin granules are appropriate to prescribe as a licensed preparation that supports timely treatment.

SUPPLY:

Vancomycin and fidaxomicin are not routinely stocked in community pharmacies but are usually obtainable on next-day delivery. However, at weekends and bank holidays, a local arrangement has been put in place whereby a small number of pharmacies will hold supplies. Please refer to the document below called "Supply of oral vancomycin and fidaxomicin for treating Clostridioides difficile in Primary Care - Mar 23"