Formulary Search

To be initiated by a specialist.

For ADULTS, blue with specialist prescriber initation and supply for at least 12 weeks

Non-formulary for CHILDREN.

Licensed for use in adults only

Ensure that the patient is maintained on a specific manufacturer’s product. Phenytoin sodium is NOT EQUIVALENT to Phenytoin base (suspension). When switching between products, 100mg of phenytoin sodium is approximately equivalent to 92mg of phenytoin base.

https://www.gov.uk/drug-safety-update/phenytoin-risk-of-stevens-johnson-syndrome-associated-with-hla-b-1502-allele-in-patients-of-thai-or-han-chinese-ethnic-origin

https://www.gov.uk/drug-safety-update/antiepileptics-adverse-effects-on-bone

https://www.gov.uk/drug-safety-update/antiepileptic-drugs-in-pregnancy-updated-advice-following-comprehensive-safety-review

Pregnancy risks - https://www.gov.uk/drug-safety-update/antiepileptic-drugs-in-pregnancy-updated-advice-following-comprehensive-safety-review

Pregabalin (Lyrica): findings of safety study on risks during pregnancy - GOV.UK

Respiratory depression - https://www.gov.uk/drug-safety-update/pregabalin-lyrica-reports-of-severe-respiratory-depression

Pregnancy Prevention Plan required for females of childbearing potential - https://www.medicines.org.uk/emc/rmm/3084/Document

https://www.gov.uk/drug-safety-update/topiramate-topamax-introduction-of-new-safety-measures-including-a-pregnancy-prevention-programme

RSCH - only initiate on recommendation from a tertiary referral centre.

Pregnancy Prevention Programme required. See MHRA advice

Principles for shared care found here: https://surrey.res.services/PAD/Profile/NonClinicalProfile/9136

Pregnancy Prevention Programme required. See MHRA advice

For initiation and dose adjustments by specialists in Epilepsy only.