Semaglutide - Diabetes Mellitus

Dose titration for weight loss in diabetes:

The Surrey Heartlands Integrated Care System Area Prescribing Committee agree the following for the GLP1s (semaglutide, tirzepatide and liraglutide), when used for diabetes:

• Continue at 6 months only if HbA1c has reduced by at least 11mmol/mol (1%) and weight reduction of at least 3%
• Further dose titrations after 6 months should be in line with glycaemic control only, unless the patient meets the cohort criteria for weight management for

o   Semaglutide: joint-position-statement-on-medical-therapies-for-obesity_final-resubmitted-sfe-211223.pdf

o   Tirzepatide: PRN01879-interim-commissioning-guidance-implementation-of-the-nice-technology-appraisal-ta1026-and-the-NICE-fu.pdf

o   Liraglutide: 1 Recommendations | Liraglutide for managing overweight and obesity | Guidance | NICE

Do not prescribe Ozempic® for the treatment of obesity.

Weight Management Guidelines - for advice see Guidelines : Weight management in adults (res-systems.net)

The Surrey Heartlands integrated care system Area Prescribing Committee (APC) approve the use semaglutide (oral formulation) with a GREEN (see narrative) traffic light status.

If a GLP-1 receptor antagonist is clinically indicated,the primary care prescriber after discussion with the patient should strongly recommend initiation of a GLP-1 RA injection because of the evidence for cardiovascular benefit for that formulation.

Semaglutide (oral) is available for patients in a niche group where a GLP-1 RA injection cannot be used (due to clinical reasons or patient preference).

Oral formulation is not the preferred route of administration, due to poor bioavailability and a high incidence of gastrointestinal side effects.

The patient should be advised about the advantages of the injectable form of semaglutide over the oral form because of improved outcomes data and greater certainty that the correct dose will be administered.

Oral semaglutide should be reserved only for those few patients for whom a GLP-1 Receptor Agonist is the treatment of choice and who are:

• unable to tolerate, or unsuitable for an SGLT-2 inhibitor
• unable to tolerate the injectable preparation eg allergy to an ingredient in the injection
• psychologically unable to consider administration of a s.c. injection (even if someone else administers it)
• unable to self-administer the injection, due to physical disability or dexterity problems.

An alternative oral option for ths group of patients for consideration is a SGLT2 inhibitor, In line with current NICE guidance for managing type 2 diabetes, patients should be assessed after 6 months at the maximum tolerated dose. If the patient does not achieve targets of a 1% reduction in HbA1c and 3% reduction in weight, the treatment should be reviewed with a view to discontinuation of treatment and switching to another appropriate therapy.