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Search Results : Diabetes Mellitus (Tirzepatide - Diabetes Mellitus)
Records returned : 69 (on 29 May 2025 at 13:20:11).
Return to search results for ' Diabetes Mellitus '.
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Drug
Indication
Status
Restrictions/Comments
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Links
Indication :
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Formulations :
- Not Specified
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- Subcutaneous injection (sc)
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Important
Dulaglutide is the preferred weekly injection. Semaglutide is an alternative for weekly injections.
Tirzepatide is 3rd line where dulaglutide / semaglutide are unsuitable or unavailable.
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- Cartridges
- Pre-filled pen
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Important
Prescribe by brand and state form.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
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5. Biphasic Lispro Insulin - Humalog Mix 25
Drug:
Biphasic Lispro Insulin - Humalog Mix 25
(Insulin)
Indication :
Status :
Formulations :
- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
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6. Biphasic Lispro Insulin - Humalog Mix 50
Drug:
Biphasic Lispro Insulin - Humalog Mix 50
(Insulin)
Indication :
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Formulations :
- Not Specified
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Important
Prescribe by brand and state form.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
SASH - restricted to diabetes team initiation only.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Biosimilar insulin aspart (Trurapi) should be used in preference to NovoRapid.
Prescribe by brand and state form.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Preferred
Prescribe by brand and state form. Lower-cost biosimilar. Preferred for new patients.
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- Cartridges
- Pre-filled pen
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Important
Initiation by Diabetes team only. Prescribe by brand.
Insulin degludec is available in strengths of 100units/mL and 200units/mL - ensure correct strength is prescribed and dispensed
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- Cartridges
- Pre-filled pen
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Important
Levemir (insulin detemir Penfill / FlexPen) is being discontinued. Supplies are expected to run out by Dec 2026. It is recommended that this is not initiated in new patients.
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- Cartridges
- Pre-filled pen
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Important
Prescribe by brand and state form. Semglee (biosimilar) is a lower cost option for patients using a pre-filled pen.
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Formulations :
- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form. Semglee (biosimilar) is a lower cost option for patients using a pre-filled pen. Lantus remains an option in existing patients and those preferring a reusable pen.
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- Pre-filled pen
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Important
Preferred
Semglee (biosimilar insulin glargine) is the preferred brand for all new patients who require a pre-filled pen.
Prescribe by brand.
Note - Semglee is NOT available as cartridges for use in re-usable insulin pens.
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- Pre-filled pen
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Important
Initiation by diabetes consultants or GPs with a specialist interest in diabetes. For use in poorly controlled patients.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
SASH - restricted to diabetes team initiation only.
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Formulations :
- Cartridges
- Pre-filled pen
- Vials
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Important
Biosimilar insulin Lispro (Admelog).
Prescribe by brand and state form.
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Formulations :
- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form. Admelog (biosimilar insulin lispro) is lower cost and should be considered in preference to Humalog.
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- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
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- Cartridges
- Vials
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Important
Initiation by diabetes team only. Usage is low but available for existing patients
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- Cartridges
- Pre-filled pen
- Vials
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Important
Prescribe by brand and state form.
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- Cartridges
- Vials
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Formulations :
- Cartridges
- Vials
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Important
Prescribe by brand and state form.
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Formulations :
- Cartridges
- Vials
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Important
Initiation by diabetes team only
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- Vials
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- Cartridges
- Vials
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Important
Prescribe by brand and state form.
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- Subcutaneous injection (sc)
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Important
Preferred
Preferred GLP-1 for WEEKLY injection.
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- Tablets
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Preferred
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- Tablets
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Preferred
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Formulations :
- Modified release
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Important
Immediate release tablets are preferred
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- Modified release tablets
- Tablets
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Important
Preferred
NOTE: 1g oridnary tablets are disproportionately expensive in primary care. 1g modified release tablets are recommended.
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Formulations :
- Oral solution
- Powder
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Important
Oral solution should be reserved for patients with enteral feeding tubes or those unable to swallow tablets.
Sachets of powder for oral solution are preferred in patients with swallowing difficulties in primary care.
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- Tablets
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- Tablets
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- Tablets
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Preferred
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- Tablets
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Important
Inadequately controlled diabetes mellitus
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Formulations :
- Tablets
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Important
Type 2 diabetes.
Empagliflozin is the preferred SGLT-2
Dapagliflozin is not a preferred treatment option.
Trusts restrict to diabetic team initiation only.
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- Tablets
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Important
Not licensed in Type 1 diabetes. Not to be initiated in new Type 1 patients.
Shared care remains in place for existing patients only.
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- Tablets
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Important
Empagliflozin is the preferred SGLT2.
Reserve combination products for patients in whom separate components are less appropriate.
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Formulations :
- Tablets
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Important
Reserve combination products for patients in whom separate components are less appropriate.
Existing patients would not be expected to change therapy unless appropriate to do so.
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Formulations :
- Tablets
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Important
Empagliflozin is the preferred SGLT-2.
Ertugliflozin is a treatment option.
Trusts restrict to diabetic team initiation only.
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Formulations :
- Not Specified
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Important
Exenatide is not a preferred treatment option. The preferred GLP-1 for WEEKLY injection is dulaglutide.
Prescribing may continue on existing patients.
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- Tablets
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Important
Not a preferred treatment option.
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- Tablets
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Important
Sitagliptin is 1st line. Only consider linagliptin in patients with rapidly deteriorating renal function where there is a risk that dose reduction of sitagliptin may not take place.
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Formulations :
- Tablets
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Important
Reserve combination products for patients in whom the separate components are less appropriate
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Formulations :
- Subcutaneous injection (sc)
Restrictions / Comments:
Important
Preferred
Liraglutide is 1st-line for patients who wish to have a DAILY injection.
Dulaglutide is the preferred WEEKLY injection.
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Formulations :
- Tablets
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Important
Reserve combination products for patients in whom the separate components are less appropriate
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Indication :
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Formulations :
- Subcutaneous injection (sc)
Restrictions / Comments:
Important
Dulaglutide is 1st line.
Semaglutide is the 2nd line option for WEEKLY injection. Max of 13 Ozempic pens per patient per year (1 pen is a 4 week supply).
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- Tablets
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Important
Oral semaglutide is not a preferred route due to poor availability and gastrointestinal side effects.
Use may be appropriate in a small cohort of patients where injection isn't suitable.
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- Oral solution
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Important
Always used in combination with chlorothiazide.
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- Capsules
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Important
Unlicensed product
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- Tablets
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- Tablets
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Important
SASH restricted to specialist monogenic clinic for use in specific diabetic subtypes (unlicensed drug - hospital only prescribing)
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Formulations :
- Oral solution
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Important
Glucose 250mg per ml (75g in 300ml)
Not supplied by Pharmacy at SASH - ordered from NHS Procurement
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- Device
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- Tablets
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Important
Existing patients would not be expected to change therapy unless appropriate to do so.
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- Tablets
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Important
Sitagliptin is the preferred DPP4.
Reserve combination products for patients in whom separate components are less appropriate.
Existing patients would not be expected to change therapy unless appropriate to do so.
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Formulations :
- Tablets
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Important
Empagliflozin is the preferred SGLT2.
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Indication :
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Formulations :
- Tablets
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Formulations :
- Tablets
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Formulations :
- Injection
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Formulations :
- Tablets
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Important
Not a cost-effective option. Prescribe as separate components.
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Formulations :
- Tablets
Restrictions / Comments:
Important
Sitagliptin is the preferred DPP4. Reserve combination products for patients in whom separate components are less appropriate. Existing patients would not be expected to change therapy unless appropriate to do so.
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Formulations :
- Tablets
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Important
Existing patients would not be expected to change therapy unless appropriate to do so.
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Formulations :
- Tablets
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Formulations :
- Tablets
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Important
Sotagliflozin is not yet available in the NHS. The NICE TA622 will not be implemented until the product is available. Place in therapy will also be determined at this time.
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- Injection
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- Tablets
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Indication :
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Formulations :
- Tablets
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Important
Existing patients would not be expected to change therapy unless appropriate to do so.
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